Delivery of immunotherapy with peptide-pulsed blood in macaques.

نویسندگان

  • Robert De Rose
  • Caroline S Fernandez
  • Liyen Loh
  • Viv Peut
  • Rosemarie D Mason
  • Sheilajen Alcantara
  • Jeanette Reece
  • Stephen J Kent
چکیده

Simple and effective delivery methods for cellular immunotherapies are needed. We assessed ex vivo pulsing of overlapping SIV Gag 15mer peptides onto either whole blood or PBMC in 15 randomly assigned SIV-infected macaques. Both delivery methods were safe and immunogenic, stimulating high levels of broad and polyfunctional Gag-specific CD4 and CD8 T cells. Delivery of overlapping Gag peptides via either whole blood or PBMC is suitable for clinical evaluation.

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عنوان ژورنال:
  • Virology

دوره 378 2  شماره 

صفحات  -

تاریخ انتشار 2008